Abstract
Electron density maps of human deoxyhaemoglobin at a resolution of 3.5 Å reveal new conformations of the C-terminal residues of the β chain and confirm their contribution to the alkaline Bohr effect. A preliminary comparison of this structure with that of horse oxyhaemoglobin shows that the main differences occur at the chain termini and at certain side chains in the α1β2 interface.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Muirhead, H., Cox, J. M., Mazzarella, L., and Perutz, M. F., J. Mol. Biol., 28, 117 (1967).
Bolton, W., Cox, J. M., and Perutz, M. F., J. Mol. Biol., 33, 283 (1968).
Perutz, M. F., Muirhead, H., Mazzarella, L., Crowther, R. A., Greer, J., and Kilmartin, J. V., Nature, 222, 1240 (1969).
Kilmartin, J. V., and Rossi-Barnardi, L., Nature, 222, 1243 (1969).
Lehmann, H., and Carrell, R. W., Brit. Med. Bull., 25, 14 (1969).
Perutz, M. F., and Lehmann, H., Nature, 219, 902 (1968).
Stryer, L., Kendrew, J. C., and Watson, H. C., J. Mol. Biol., 8, 96 (1964).
Cecil, R., and Snow, N. S., Biochem. J., 82, 247 (1962).
Cecil, R., and Thomas, M. A. W., Nature, 206, 1317 (1965).
Green, D. W., Ingram, V. M., and Perutz, M. F., Proc. Roy. Soc., A, 225, 287 (1954).
Watson, H. C., Shotton, D. M., Cox, J. M., and Muirhead, H., Nature, 225, 806 (1970).
North, A. C. T., Phillips, D. C., and Mathews, F. S., Acta Cryst., 24, 351 (1968).
Dickerson, R. E., Kendrew, J. C., and Strandberg, B. E., Acta Cryst., 14, 1188 (1961).
Lipscomb, W. N., Coppola, J. C., Hartsuck, J. A., Ludwig, M. L., Muirhead, H., Searl, J., and Steitz, T. A., J. Mol. Biol., 19, 423 (1966).
Blow, D. M., and Crick, F. H. C., Acta Cryst., 12, 794 (1959).
Gossling, T. H., Acta Cryst., 22, 465 (1967).
Richards, F. M., J. Mol. Biol., 37, 225 (1968).
Nobbs, C. L., Watson, H. C., and Kendrew, J. C., Nature, 209, 339 (1966).
Perutz, M. F., Muirhead, H., Cox, J. M., Goaman, L. C. G., Mathews, F. S., McGandy, E. L., and Webb, L. E., Nature, 219, 29 (1968).
Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968).
Perutz, M. F., J. Mol. Biol., 13, 646 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MUIRHEAD, H., GREER, J. Three-dimensional Fourier Synthesis of Human Deoxyhaemoglobin at 3.5 Å Resolution. Nature 228, 516–519 (1970). https://doi.org/10.1038/228516a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/228516a0
This article is cited by
-
Structure of leghaemoglobin from lupin root nodules at 5 Å resolution
Nature (1975)
-
Molecular structure, quadrupole splitting, and magnetic susceptibility of iron in deoxygenated myoglobin and hemoglobin
Theoretica Chimica Acta (1975)
-
X-ray Studies of the Interaction of CO2 with Human Deoxyhaemoglobin
Nature (1974)
-
Structure of inositol hexaphosphate–human deoxyhaemoglobin complex
Nature (1974)
-
Die Pathophysiologie der Struktur- und Funktionsvarianten des H�moglobins
Klinische Wochenschrift (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.