Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Evidence that the Area Postrema mediates the Central Cardiovascular Response to Angiotensin II

Abstract

ANGIOTENSIN can affect the cardiovascular system in several different ways. Its direct vasoconstrictor action is well recognized but it can also exert cardiovascular effects by stimulating the autonomic nervous system at a variety of sites including the adrenal medulla1, the sympathetic ganglia2, the post-ganglionic sympathetic nerve terminals3 and the brain4. It has not been possible, so far, to quantitate the relative importance of these various effects of the hormone in either physiological or pathological circumstances.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Feldberg, W., and Lewis, G. P., J. Physiol., 171, 98 (1964).

    Article  CAS  Google Scholar 

  2. Lewis, G. P., and Reit, E., J. Physiol., 179, 538 (1965).

    Article  CAS  Google Scholar 

  3. Zimmerman, B. C., Circ. Res., 11, 780 (1962).

    Article  CAS  Google Scholar 

  4. Bickerton, R. K., and Buckley, J. P., Proc. Soc. Exp. Biol. Med., 106, 834 (1961).

    Article  CAS  Google Scholar 

  5. Scroop, G. C., and Lowe, R. D., Clin. Sci., 37, 605 (1969).

    CAS  PubMed  Google Scholar 

  6. Lowe, R. D., and Scroop, G. C., Clin. Sci., 37, 593 (1969).

    CAS  PubMed  Google Scholar 

  7. Joy, M. D., and Lowe, R. D., Clin. Sci., 39, 327 (1970).

    Article  CAS  Google Scholar 

  8. Wislocki, G. B., and Putnam, T. J., Anat. Rec., 19, 281 (1920).

    Article  Google Scholar 

  9. Wislocki, G. B., and Putnam, T. J., Anat. Rec., 27, 151 (1924).

    Article  Google Scholar 

  10. Clemente, C. D., J. Physiol., 124, 23P (1954).

    CAS  PubMed  Google Scholar 

  11. Brizzee, K. R., and Neal, L. M., J. Comp. Neurol., 100, 41 (1954).

    Article  CAS  Google Scholar 

  12. Borison, H. L., and Brizzee, K. R., Proc. Soc. Exp. Biol. Med., 77, 38 (1951).

    Article  CAS  Google Scholar 

  13. Scroop, G. C., J. Physiol., 204, 106P (1969).

    CAS  PubMed  Google Scholar 

  14. Lavery, H., Lowe, R. D., and Scroop, G. C., J. Physiol., 204, 109P (1969).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

JOY, M., LOWE, R. Evidence that the Area Postrema mediates the Central Cardiovascular Response to Angiotensin II. Nature 228, 1303–1304 (1970). https://doi.org/10.1038/2281303a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2281303a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing