Abstract
ANGIOTENSIN can affect the cardiovascular system in several different ways. Its direct vasoconstrictor action is well recognized but it can also exert cardiovascular effects by stimulating the autonomic nervous system at a variety of sites including the adrenal medulla1, the sympathetic ganglia2, the post-ganglionic sympathetic nerve terminals3 and the brain4. It has not been possible, so far, to quantitate the relative importance of these various effects of the hormone in either physiological or pathological circumstances.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Feldberg, W., and Lewis, G. P., J. Physiol., 171, 98 (1964).
Lewis, G. P., and Reit, E., J. Physiol., 179, 538 (1965).
Zimmerman, B. C., Circ. Res., 11, 780 (1962).
Bickerton, R. K., and Buckley, J. P., Proc. Soc. Exp. Biol. Med., 106, 834 (1961).
Scroop, G. C., and Lowe, R. D., Clin. Sci., 37, 605 (1969).
Lowe, R. D., and Scroop, G. C., Clin. Sci., 37, 593 (1969).
Joy, M. D., and Lowe, R. D., Clin. Sci., 39, 327 (1970).
Wislocki, G. B., and Putnam, T. J., Anat. Rec., 19, 281 (1920).
Wislocki, G. B., and Putnam, T. J., Anat. Rec., 27, 151 (1924).
Clemente, C. D., J. Physiol., 124, 23P (1954).
Brizzee, K. R., and Neal, L. M., J. Comp. Neurol., 100, 41 (1954).
Borison, H. L., and Brizzee, K. R., Proc. Soc. Exp. Biol. Med., 77, 38 (1951).
Scroop, G. C., J. Physiol., 204, 106P (1969).
Lavery, H., Lowe, R. D., and Scroop, G. C., J. Physiol., 204, 109P (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JOY, M., LOWE, R. Evidence that the Area Postrema mediates the Central Cardiovascular Response to Angiotensin II. Nature 228, 1303–1304 (1970). https://doi.org/10.1038/2281303a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2281303a0
This article is cited by
-
Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis
Basic Research in Cardiology (2018)
-
Organ Selective Regulation of Sympathetic Outflow by the Brain Angiotensin System
Current Hypertension Reports (2013)
-
Peripheral modulation of learning and memory: enkephalins as a model system
Psychopharmacology (1992)
-
Effects of the angiotensin converting enzyme inhibitor, benazepril, on the sino-aortic baroreceptor heart rate reflex
Cardiovascular Drugs and Therapy (1991)
-
The area postrema and the hypertensive effect of angiotensin
Metabolic Brain Disease (1989)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.