Abstract
ALTHOUGH proton magnetic resonance spectroscopy has improved our knowledge of the structure and function of biopolymers, especially complex peptides and proteins1, it has not yet solved such problems as determining the conformation of a protein in solution. The nearest approach has been the analysis of the spectrum of gramicidin S-A2, a peptide of molecular weight 1,120 (Fig. 1). The technique used there is theoretically applicable to biopolymers of higher molecular weight, but the experimental difficulties are almost insurmountable.
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GIBBONS, W., SOGN, J., STERN, A. et al. 13C Nuclear Magnetic Resonance Spectrum of Gramicidin S-A, a Decapeptide Antibiotic. Nature 227, 840–842 (1970). https://doi.org/10.1038/227840a0
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DOI: https://doi.org/10.1038/227840a0
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