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Localization of Afferent Lymph Cells within the Draining Node during a Primary Immune Response

Nature volume 227, pages 510–513 (1970)Cite this article

Abstract

LYMPH nodes can receive cells from the blood and from the lymph. The principal pathway from the blood into the nodes is through the post capillary venules in the paracortex1, the second is through the afferent lymphatics. The number of cells in the afferent lymph increases after the injection of an antigen into the drainage area2, but their localization in the node and their role in mediating the immune response are unknown. Obstruction of the lymphatics reduces the size and number of germinal centres within the node3, suggesting a relationship between these structures and the afferent lymph. The work reported here was concerned with the kinetics of the cellular response in the afferent lymph after antigenic stimulation and the fate of these cells within the node.

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  1. Immunology Division, National Institute for Medical Research, Mill Hill, London, NW7

    R. H. KELLY

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  1. R. H. KELLY
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KELLY, R. Localization of Afferent Lymph Cells within the Draining Node during a Primary Immune Response. Nature 227, 510–513 (1970). https://doi.org/10.1038/227510a0

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  • DOI: https://doi.org/10.1038/227510a0

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