Model for DNA Replication by Kornberg's DNA Polymerase

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Abstract

Experimental evidence is given for a model in which DNA replicates with the two growing daughter strands covalently linked by a pyrophosphate bridge. The two strands are synthesized synchronously in opposite directions, one 5′ to 3′ and the other 3′ to 5′.

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MORGAN, A. Model for DNA Replication by Kornberg's DNA Polymerase. Nature 227, 1310–1313 (1970) doi:10.1038/2271310a0

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