Resistance of Mice and Rats to Challenge by Babesia rodhaini after Inoculation with Irradiated Red Cells infected with B. rodhaini

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Abstract

FIELD vaccination of cattle against babesia parasites is performed by infecting with a strain of low virulence1. This unfortunately ensures continued transmission of the disease. Some resistance has been induced experimentally in rats2,3 and cattle4 by injection of killed piroplasms using large amounts of parasite antigen, often combined with an adjuvant. I present here a preliminary account of successful protective immunization of mice and rats against the piroplasm Babesia rodhaini using irradiated piroplasms.

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References

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    Callow, L. L., and Tammemagi, L., Austral. Vet. J., 43, 249 (1967).

  2. 2

    Phillips, R. S., Parasitology, 11P (1967).

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    Phillips, R. S., thesis, Univ. Cambridge (1968).

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    Mahoney, D. F., Exp. Parasitol., 20, 125 (1967).

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    Voller, A., and Bidwell, D. E., Ann. Trop. Med. Parasitol., 62, 342 (1968).

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    Lumsden, W. H. R., and Hardy, G. T. C., Nature, 250, 1032 (1965).

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    Phillips, R. S., Parasitology, 59, 349 (1969).

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PHILLIPS, R. Resistance of Mice and Rats to Challenge by Babesia rodhaini after Inoculation with Irradiated Red Cells infected with B. rodhaini. Nature 227, 1255 (1970) doi:10.1038/2271255a0

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