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DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses

Abstract

Besides having RNA-dependent DNA polymerase activity, oncogenic RNA viruses possess a DNA-directed DNA polymerase which is distinguished from previously described enzymes of this type in preferring double-stranded DNA as template and yielding a principally double-stranded product.

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References

  1. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970).

    Article  ADS  CAS  Google Scholar 

  2. Baltimore, D., Nature, 226, 1209 (1970).

    Article  ADS  CAS  Google Scholar 

  3. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 227, 563 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Kornberg, A., Enzymatic Synthesis of DNA, 103 (John Wiley, New York and London, 1961).

    Google Scholar 

  5. Goulian, M., Kornberg, A., and Sinsheimer, R. L., Proc. US Nat. Acad. Sci., 58, 2321 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Denhardt, D. T., Biochem. Biophys. Res. Commun., 23, 641 (1966).

    Article  CAS  Google Scholar 

  7. Gillespie, D., and Spiegelman, S., J. Mol. Biol., 12, 829 (1965).

    Article  CAS  Google Scholar 

  8. Warnaar, S. O., and Cohen, J. H., Biochem. Biophys. Res. Commun., 24, 554 (1966).

    Article  CAS  Google Scholar 

Download references

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SPIEGELMAN, S., BURNY, A., DAS, M. et al. DNA-directed DNA Polymerase Activity in Oncogenic RNA Viruses. Nature 227, 1029–1031 (1970). https://doi.org/10.1038/2271029a0

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  • DOI: https://doi.org/10.1038/2271029a0

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