Abstract
INVESTIGATIONS into the presence of histocompatibility antigens in mouse brain have given apparently conflicting results. Haemagglutinin1,2 and cytotoxin3 inhibition studies have revealed that the brain has an extremely small capacity for absorbing H-2 antibodies, compared with lymphoid tissues. Brain tissue, however, induces transplantation immunity4 and histocompatibility antigens are detected in neurones of the cerebral cortex by immuno-fluorescence5. The selective localization of the specific fluorescence to the neurones can explain these conflicting results, for the number of stained cells represents only a small proportion of the total brain tissue. This will be reflected by a very low absorptive capacity in quantitative inhibition studies.
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GERVAIS, A. Transplantation Antigens in the Central Nervous System. Nature 225, 647 (1970). https://doi.org/10.1038/225647a0
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DOI: https://doi.org/10.1038/225647a0
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