Letter | Published:

Alcohol-induced Malabsorption of Vitamin B12 in Man

Nature volume 224, page 806 (22 November 1969) | Download Citation

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Abstract

INTOXICATION with alcohol is frequently associated with diarrhoea, and disturbances of intestinal function have been reported to be common in chronic alcoholics studied shortly after drinking-bouts1–5. Because the normal diet of alcoholics is characteristically poor, it is not clear whether the transient malabsorption frequently found can be attributed to a direct toxic effect of ethanol on the small intestine, or to a nutritional deficiency. We therefore studied the effects of the experimental ingestion of ethanol in man on vitamin B12 absorption under controlled metabolic ward conditions in the absence of nutritional deficiency.

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Author information

Affiliations

  1. Department of Medicine, Columbia University, and Harlem Hospital Center.

    • JOHN LINDENBAUM
  2. Department of Medicine, Mount Sinai School of Medicine, and Section of Liver Disease and Nutrition, Bronx Veterans Administration Hospital, New York.

    • CHARLES S. LIEBER

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DOI

https://doi.org/10.1038/224806a0

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