Abstract
Four principal features of cellular immunity in the guinea-pig are mediated by a group of soluble factors generated by antigen-activated lymphocytes. These “lymphokines” are different from classical antibodies.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Benacerraf, B., and Levine, B. B., J. Exp. Med., 115, 1023 (1962); Mackaness, G. B., ibid., 120, 105 (1964); Schlossman, S., Ben-Ephraim, S., Yaron, A., and Sober, H. A., ibid, 123, 1083 (1966).
Mitchison, N. A., Prog. Biophys. Chem., 16, 3 (1966); Dutton, R. W., Adv. Immunol, 6, 254 (1967); Paul, W. E., Siskind, G. W., and Benacerraf, B., J. Exp. Med., 127, 25 (1968).
Gell, P. G. H., Brit. Med. Bull., 23, 1 (1967).
Bloom, B. R., and Chase, M. W., Progr. Allergy, 10, 1 (1967).
Ling, N. R., Lymphocyte Stimulation (North-Holland, Amsterdam, 1968).
Perlmann, P., and Holm, G., in Immunopathology, Fifth International Symposium 1967 (edit. by Miescher, P. A., and Grabar, P.), 325 (Schwabe Basel, 1968).
Dumonde, D. C., Brit. Med. Bull., 23, 9 (1967).
David, J. R., Fed. Proc., 27, 6 (1968).
Garlick, D. G., Austral. J. Exp. Biol. Med. Sci., 43, 671 (1965).
Morley, J., and Dumonde, D. C., Proc. Intern. Conf. Microcirculation, Gothenburg 1968, Acta Anatomica (in the press).
Dumonde, D. C., Howson, W. T., and Wolstencroft, R. A., in Immunopathology, Fifth Internal. Symp. 1967 (edit. by Miescher, P. A., and Grabar, P.), 263 (Schwabe, Basel, 1968).
Oppenheim, J. J., Wolstencroft, R. A., and Gell, P. G. H., Immunology, 12, 89 (1967).
Wolstencroft, R. A., and Dumonde, D. C., Immunology (submitted for publication).
McFarlane, A. S., Nature, 182, 53 (1958).
Bennett, B., and Bloom, B. R., Proc. US Nat. Acad. Sci., 59, 576 (1968).
Voisin, G. A., and Tollet, F., in Cellular Aspects of Immunity, Ciba Foundation Symposium, 373 (Churchill, London, 1960).
Waksman, B. H., and Matoltsy, M., J. Immunol., 81, 220 (1958).
Miles, A. A., Ann. NY Acad. Sci., 116, 855 (1964).
Fisher, D. B., and Mueller, G. C., US Nat. Acad. Sci., 60, 1396 (1968); Borberg, H., Woodruff, J. J., Hirschhorn, R., Gesner, B., Miescher, P., and Sibler, R., Science, 154, 1019 (1966).
Oppenheim, J. J., Fed. Proc., 27, 2 (1968).
Maini, R. N., Bryceson, A. D. M., Wolstencroft, R. A., and Dumonde, D. C., Nature, 224, 43 (1969) (following article).
Granger, G. A., and Williams, T. W., Nature, 218, 1253 (1968); Kolb, W. P., and Granger, G. A., Proc. US Nat. Acad. Sci., 61, 1250 (1968); Granger, G. A., Shacks, S. J., Williams, T. W., and Kolb, W. P., Nature, 221, 1155 (1969); Ruddle, N. H., and Waksman, B. H., J. Exp. Med., 128, 1267 (1968).
Wilson, D. B., J. Exp. Med., 122, 143 (1965); Perlmann, P., Perlmann, H., Müller-Eberhard, H. J., and Manni, J. R., Science, 163, 937 (1969).
Willmer, E. N., Cytology and Evolution (Academic Press, New York, 1960).
Barnet, K., Pekarek, J., and Johanovsky, J., Experientia, 24, 9 (1968).
Bray, R. S., and Bryceson, A. D. M., Lancet, ii, 898 (1968).
Dannenberg, A. M., Meyer, O. T., Esterly, J. R., and Kambara, T., J. Immunol., 100, 931 (1968).
Dumonde, D. C., and Glynn, L. E., J. Path. Bact., 90, 649 (1965).
Thor, D. E., and Dray, S., J. Immunol., 101, 469 (1968); Jureziz, R. E., Thor, D. E., and Dray, S., ibid., 101, 823 (1968); Wilson, D. B., and Wecker, E. E., J. Immunol., 97, 512 (1966).
Wolstencroft, R. A., Matthew, M., Panayi, G. S., Morley, J., and Dumonde, D. C. (1969) (in preparation).
Laki, K., Fibrinogen (Arnold, London, 1968).
Mackay, M., Brit. Med. Bull., 20, 189 (1964).
Wilhelm, D. L., in The Inflammatory Process (edit. by Zweifach, B. W., Grant, L., and McCluskey, R. T.), 389 (Academic Press, New York, 1965).
Shin, H. S., and Mayer, M. M., Biochemistry, 7, 2997 (1968).
Humphrey, J. H., Brit. Med. Bull., 23, 93 (1967).
Benacerraf, B., in The Inflammatory Process (edit. by Zweifach, B. W., Grant, L., and McCluskey, R. T.), 241 (Academic Press, New York, 1965); Spector, W. G., Brit. Med. Bull., 23, 39 (1967).
Dumonde, D. C., J. Clin. Path., suppl., 20, 430 (1967).
Brent, L., and Medawar, P. B., Brit. Med. Bull., 23, 55 (1967).
Mackaness, G. B., and Blanden, R. V., Progr. Allergy, 11, 89 (1967); Krejci, J., Svejcar, J., Pekarek, J., and Johanovsky, J., Z. Immunforsch., 136, 259 (1968).
Dumonde, D. C., Adv. Immunol., 5, 263 (1966).
Bretscher, P. A., and Cohn, M., Nature, 220, 444 (1968); Kolsch, E., and Mitchison, N. A., J. Exp. Med., 128, 1059 (1968).
Turk, J. L., Brit. Med. Bull., 23, 3 (1967); Wakefield, J. D., and Thorbecke, J., J. Exp. Med., 128, 153 (1968).
Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).
Burnet, F. M., Nature, 218, 426 (1968).
Jerne, N. K., Cold Spring Harbor Symp. Quant. Biol., 32, 591 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DUMONDE, D., WOLSTENCROFT, R., PANAYI, G. et al. “Lymphokines”: Non-Antibody Mediators of Cellular Immunity generated by Lymphocyte Activation. Nature 224, 38–42 (1969). https://doi.org/10.1038/224038a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/224038a0
This article is cited by
-
MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle
Heart Failure Reviews (2017)
-
The meteorology of cytokine storms, and the clinical usefulness of this knowledge
Seminars in Immunopathology (2017)
-
Effect of Kalpaamruthaa on immunosuppression of both humoral and cell-mediated immunity in DMBA-induced mammary tumours of rats
Comparative Clinical Pathology (2015)
-
Macrophages and cytokines in the early defence against herpes simplex virus
Virology Journal (2005)
-
The use of anakinra in juvenile arthritis
Current Rheumatology Reports (2005)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.