Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei


RECENTLY interest has revived in the activity of the sulphonamides and sulphones against strains of malaria parasites, especially P. falciparum, that are resistant to other drugs such as chloroquine and pyrimethamiiie1. A number of acridine derivatives, including mepacrine, prevent the emergence in vitro of resistance to sulphonamides and certain antibiotics in Staphylococcus spp.2,3. Because mepacrine itself is a potential antimalarial blood schizontocide it seemed of interest to explore whether the simultaneous administration of mepacrine and a sulphonamide in malaria would result in any change in the pattern of development of resistance of the parasites to either drug.

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PETERS, W. Partial Inhibition by Mepacrine of the Development of Sulphonamide Resistance in Plasmodium berghei. Nature 223, 858–859 (1969).

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