Congenital Transmission in Mice of an Active Agent from Human Rheumatoid Arthritis


RHEUMATOID arthritis is the major cause of crippling today. The aetiology is unknown1–5, but the theory of a slow growing virus has attracted great interest6 and has led to our experiments. A transmissible acute and chronic polyarthritis has been consistently induced in mice and their litters with injections of synovial tissues obtained from rheumatoid arthritis patients. After 14 months of breeding and injection of 2,300 newborn mice, we find the disease can remain latent in females for a year and that it can be congenitally transmitted through at least three generations. There is a remarkable resemblance between rheumatoid arthritis and the disease produced in the experimental mice.

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WARREN, S., MARMOR, L., LIEBES, D. et al. Congenital Transmission in Mice of an Active Agent from Human Rheumatoid Arthritis. Nature 223, 646–647 (1969).

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