New Potent Blood Sugar Lowering Compound


HYPOGLYCAEMIC activity has not so far been reported in any 4-quinazolone derivatives. We have found that 2-piperazino-3H,4-quinazolone monoacetate (I; 68/157) is an effective blood sugar lowering agent (patent pending). This compound was synthesized by heating 2-ethylthio-3H,4-quinazolone with N-benzylpiperazine followed by debenzylation with H2 over Pd/C in glacial acetic acid.

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GUPTA, C., HUSAIN, S., BHADURI, A. et al. New Potent Blood Sugar Lowering Compound. Nature 223, 524 (1969).

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