Skin Transplantation: Orientation of Epithelial Cells by the Basement Membrane


IN spite of extensive studies of the histological changes in skin transplants1,2, little attention has been paid to the behaviour of donor and host epidermis. We find that the epidermis in skin autografts and homografts is formed de novo by a proliferation of the host epidermis and an outgrowth from the hair follicles of the graft. In each case the newly formed cells migrate over the basement membrane of the grafted epidermis. We have followed these migratory movements in twelve full-thickness autografts and homografts on the scalps of four male rhesus monkeys (Macaca mulatta) using a technique described before2.

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GIACOMETTI, L., PARAKKAL, P. Skin Transplantation: Orientation of Epithelial Cells by the Basement Membrane. Nature 223, 514–515 (1969).

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