Abstract
IN spite of extensive studies of the histological changes in skin transplants1,2, little attention has been paid to the behaviour of donor and host epidermis. We find that the epidermis in skin autografts and homografts is formed de novo by a proliferation of the host epidermis and an outgrowth from the hair follicles of the graft. In each case the newly formed cells migrate over the basement membrane of the grafted epidermis. We have followed these migratory movements in twelve full-thickness autografts and homografts on the scalps of four male rhesus monkeys (Macaca mulatta) using a technique described before2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Medawar, P. B., J. Anat., 78, 176 (1944).
Allegra, F., and Giacometti, L., Acta Derm. Venereol., 48, 429 (1968).
Lillie, R. D., Histopathologic Technic and Practical Histochemistry (third ed.), 95 (McGraw-Hill Book Co., New York, 1965).
Messier, B., and Leblond, C. P., Proc. Soc. Exp. Biol. and Med., 97, 7 (1957).
Pease, D. C., in Histological Techniques for Electron Microscopy (Academic Press, New York, 1964).
Hay, E. D., and Revel, J. P., Develop. Biol., 7, 152 (1963).
Pierce, G., Barry, J., and Nakane, P. K., Lab. Invest., 17, 499 (1967).
Weiss, P., in Wound Healing and Tissue Repair (edit. by Bradford Patterson, W.) (University of Chicago Press, Chicago, 1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GIACOMETTI, L., PARAKKAL, P. Skin Transplantation: Orientation of Epithelial Cells by the Basement Membrane. Nature 223, 514–515 (1969). https://doi.org/10.1038/223514a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/223514a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.