Movement of Fibroblasts in a Spatially Confined System


CELL movement in vitro is influenced by several mechanisms including chemotaxis, contact guidance, contact inhibition and associative movement1,2. In an effort to assess these mechanisms, the movement of chick fibroblasts isolated within capillary tubes was investigated using the techniques of Twitty and Niu3. Cells isolated within capillary tubes had a unique experimental environment, for movement was confined primarily to one spatial dimension, convection currents were avoided, and diffusion of cellular products was minimized.

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    Abercrombie, M., Nat. Cancer Inst. Monog., 26, 249 (1967).

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    Curtis, A. S. G., The Cell Surface, (Logos Press, London, 1967).

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    Twitty, V. C., and Niu, M. C., J. Exp. Zool., 125, 541 (1954).

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    Paul, J., Cell and Tissue Culture, (Williams and Wilkins, Baltimore, 1965).

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    Abercrombie, M., and Gitlin, G., Proc. Soc. Biol. Sci., 162, 289 (1965).

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JAUCH, R., DECOSSE, J. Movement of Fibroblasts in a Spatially Confined System. Nature 223, 513–514 (1969).

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