Abstract
In haemoglobin H disease, excess β chains form haemoglobin tetramers which are unstable and which readily precipitate to form inclusion bodies. Electron paramagnetic resonance and spectroscopic evidence indicates that the precipitated haemoglobin is in the form of a haemichrome.
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RACHMILEWITZ, E., PEISACH, J., BRADLEY, T. et al. Role of Haemichromes in the Formation of Inclusion Bodies in Haemoglobin H Disease. Nature 222, 248–250 (1969). https://doi.org/10.1038/222248a0
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DOI: https://doi.org/10.1038/222248a0
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