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Significance of a Complement-fixing Antigen associated with Herpes-like Virus and detected in the Raji Cell Line

Nature volume 222, pages 186–187 (1969)Cite this article

Abstract

HERPES-LIKE virus (HLV) similar to that first detected in cultured Burkitt lymphoma1 cells was subsequently demonstrated in many other human leucocyte cell lines2–5. Although no readily applicable bioassay is available for HLV, in vitro transformation of normal human leucocytes was demonstrated by co-cultivation with X-irradiated Burkitt lymphoma cells6 and by inoculation of filtrates of leucocyte lines of leukaemic7 and Burkitt lymphoma8 origin, and some evidence was presented that this transformation was caused by HLV. The presence of HLV in a small proportion of cultured cells has usually been demonstrated either directly by electron microscopy1 or indirectly by immunofluorescence (IF) tests9–11. In human sera, complement-fixing (CF) antibody to crude antigens of leucocyte cell lines containing HLV is associated with IF antibody, suggesting some relationship between HLV and the CF antigen9,12. Virion13 and soluble12 components contributed to the activity of several CF antigens studied so far.

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  1. Queensland Institute of Medical Research, Herston Road, Brisbane

    J. H. POPE, M. K. HORNE & E. J. WETTERS

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  1. J. H. POPE
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POPE, J., HORNE, M. & WETTERS, E. Significance of a Complement-fixing Antigen associated with Herpes-like Virus and detected in the Raji Cell Line. Nature 222, 186–187 (1969). https://doi.org/10.1038/222186a0

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