Letter | Published:

Malignant Transformation of Hamster Cells by Cell-free Extracts of Bovine Papillomas (in vitro)

Naturevolume 222pages12831284 (1969) | Download Citation



BOVINE papilloma virus (BPV), which is closely related to polyoma, SV-40 and other papilloma viruses1,2, induces a transformation in animal tissue cultures of various origins3–5. This transformation has been defined by the alterations in cell morphology, growth rate and pattern, and rate of acid production. Neoplastic transformation, defined as the capacity of a cell population to give rise to progressive tumour growth after injection into compatible host, has not been demonstrated so far; attempts to graft the transformed cells into animals produced no evidence of tumour formation3–5. In this communication I report the induction of tumours in hamsters by inoculation of hamster embryo cells transformed in vitro by BPV.

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    Olson, C., Ann. NY Acad. Sci., 108, 1042 (1963).

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    Levy, J. P., Boiron, M., Haguenau, F., Hollmann, K., Thomas, M., and Friedmann, J. C., J. Microscopie, 2, 175 (1963).

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    Black, P. H., Hartley, J. W., Rowe, W. P., and Huebner, R. J., Nature, 199, 1016 (1963).

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    Thomas, M., Levy, J. P., Tanzer, J., Boiron, M., and Bernard, J., CR Acad. Sci., 257, 2155 (1963).

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    Thomas, M., Boiron, M., Tanzer, J., Levy, J. P., and Bernard, J., Nature, 202, 709 (1964).

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  1. Laboratory of Cell Biology, Gulbenkian Institute of Science, Oeiras, Portugal



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