Letter | Published:

Mechanism of Coupling of Oxidative Phosphorylation and the Membrane Potential of Mitochondria

Nature volume 222, pages 10761078 (14 June 1969) | Download Citation

Subjects

Abstract

THE existence of an electrical potential difference at the mitochondrial membrane is one of the postulates of Mitchell's chemiosmotic theory of oxidative phosphorylation1,2. A shunting of the mitochondrial membrane leads to the uncoupling of oxidative phosphorylation. It has been demonstrated that uncoupling agents increase the proton permeability of phospholipid micelle membranes3 and artificial bimolecular membranes4–7. Mitchell and Moyle8 showed that uncouplers can operate as proton carriers in mitochondrial membranes.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Nature, 191, 144 (1961).

  2. 2.

    , Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation (Glynn Research Laboratories, Bodmin, 1966).

  3. 3.

    , and , in Biochemistry of Mitochondria (edit. by Slater, E. C., Kaniuga, Z., and Wojctzak, L.), 75 (Academic Press, London, 1967).

  4. 4.

    , , , and , Biofizika (USSR), 13, 188 (1968).

  5. 5.

    , , , , , and , Currents in Modern Biology, 2, 98 (1968).

  6. 6.

    , and , Biofizika (USSR), 13, 1025 (1968).

  7. 7.

    , , and , Proc. US Nat. Acad. Sci., 59, 484 (1968).

  8. 8.

    , and , Biochem. J., 105, 1147 (1967).

  9. 9.

    , and , Biochim. Biophys. Acta, 81, 214 (1964).

  10. 10.

    , , and , Biochim. Biophys. Acta, 28, 475 (1956).

  11. 11.

    , , , and , J. Phys. Chem., 67, 534 (1963).

  12. 12.

    , and , Biofizika (USSR), 14, 562 (1969).

  13. 13.

    , and , Biochem. Biophys. Res. Commun., 15, 562 (1964).

  14. 14.

    , and , in Regulation of Metabolic Processes in Mitochondria (edit. by Tager, J. M., Papa, S., Quagliarello, E., and Slater, E. C.), 293 (Elsevier, Amsterdam, 1966).

  15. 15.

    , and , in Biochemistry of Mitochondria (edit. by Slater, E. C., Kaniuga, Z., and Wojtczak, Z.), 53 (Academic Press, London, 1967).

Download references

Author information

Affiliations

  1. Institute of the Problems of Information Transmission, USSR Academy of Sciences, Moscow.

    • E. A. LIBERMAN
    • , V. P. TOPALY
    •  & L. M. TSOFINA
  2. Department of Bioenergetics, Laboratory of Bioorganic Chemistry, Moscow State University, USSR.

    • A. A. JASAITIS
    •  & V. P. SKULACHEV

Authors

  1. Search for E. A. LIBERMAN in:

  2. Search for V. P. TOPALY in:

  3. Search for L. M. TSOFINA in:

  4. Search for A. A. JASAITIS in:

  5. Search for V. P. SKULACHEV in:

About this article

Publication history

Received

Revised

Published

DOI

https://doi.org/10.1038/2221076a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.