Abstract
SIMILARITIES between leukaemia in mouse and man, together with the unequivocal viral aetiology of the murine disease, have led to the study of murine leukaemia as a model for the human disease. Levine and his associates1 reported a positive correlation between the clinical status of leukaemic patients and the incidence of virus-like particles in their plasma. For future aetiological investigations it seemed necessary to corroborate this finding in a system of known aetiology. Detection of virions by electron microscopy, as well as the isolation of infectious leukaemia virus before development of clinical leukaemia, has been repeatedly demonstrated in mice2. Quantitative work on the relationship between virions and the stage of leukaemogenesis has not, however, been reported.
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RICH, M., SIEGLER, R. & JOHNS, L. Relationship between Virion Incidence and Pathological Stage in Virus-induced Leukaemia. Nature 221, 868–869 (1969). https://doi.org/10.1038/221868a0
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DOI: https://doi.org/10.1038/221868a0
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