Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus


Engel and Forbes1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen3 proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded3 that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.

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BURCH, P. Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus. Nature 221, 175–177 (1969). https://doi.org/10.1038/221175a0

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