Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus

Abstract

Engel and Forbes1,2 noted that chromosomal non-disjunction commonly occurs in families with a genetic predisposition to “autoimmunity”. From a review of the literature, and a study of eighteen patients with chromatin-positive Klinefelter's syndrome, Nielsen3 proposed that this syndrome is probably associated with dizygotic twinning. He also summarized the results of three surveys which indicate that the frequency of twin births in sibships containing Turner's syndrome is about twice that in the general population. He concluded3 that similar mechanisms may be responsible for sex chromosome non-disjunction and dizygotic twinning.

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References

  1. 1

    Engel, E., and Forbes, A. P., Harper Hosp. Bull., 21, 83 (1963).

    Google Scholar 

  2. 2

    Engel, E., Lancet, i, 1271 (1967).

  3. 3

    Nielsen, J., J. Med. Genet., 3, 77 (1966).

    Article  Google Scholar 

  4. 4

    Registrar General's Statistical Review of England and Wales for the Year 1956, Part III (HMSO, London, 1958).

  5. 5

    Eriksson, A. W., and Fellman, J., Acta Genet. Basel, 17, 385 (1967).

    CAS  PubMed  Google Scholar 

  6. 6

    Shipley, P. W., Wray, J. A., Hechter, H. H., Arellano, M. G., and Borhani, N. O., Amer. J. Epidemiol., 85, 147 (1967).

    CAS  Article  Google Scholar 

  7. 7

    Mackay, I. R., and Burnet, F. M., Autoimmune Disease (Thomas, Springfield, Illinois, 1963).

    Google Scholar 

  8. 8

    Burch, P. R. J., An Inquiry Concerning Growth, Disease and Ageing (Oliver and Boyd, Edinburgh, 1968).

    Google Scholar 

  9. 9

    Nielsen, J., Lancet, i, 1376 (1966).

  10. 10

    Menzinger, G., Fallucca, F., and Andreani, D., Lancet, ii, 747 (1966).

  11. 11

    Wais, S., and Salvati, E., Lancet, ii, 747 (1966).

  12. 12

    Zuppinger, K., Engel, E., Forbes, A. P., Mantooth, L., and Claffey, J., Acta Endocrinol., Suppl. 113, 54, 5 (1967).

    Article  Google Scholar 

  13. 13

    Spiegelman, M., and Marks, H. H., Amer. J. Publ. Health, 36, 26 (1946).

    CAS  Article  Google Scholar 

  14. 14

    Burch, P. R. J., Rowell, N. R., and Burwell, R. G., Lancet, ii, 170 and 748 (1966).

  15. 15

    Nielsen, J., Lancet, ii, 748 (1966).

  16. 16

    Vallotton, M. B., and Forbes, A. P., Lancet, i, 648 (1967).

  17. 17

    Burch, P. R. J., and Burwell, R. G., Quart. Rev. Biol., 40, 252 (1965).

    Article  Google Scholar 

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BURCH, P. Klinefelter's Syndrome, Dizygotic Twinning and Diabetes Mellitus. Nature 221, 175–177 (1969). https://doi.org/10.1038/221175a0

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