Abstract
IT has been observed consistently that the immune responsiveness of neonatally thymectomized mice to various antigens, including bovine serum albumin (BSA), can be restored by injection of sufficient dissociated thymus cells1,2. This is also true for mice thymectomized in adult life, lethally irradiated and injected with bone marrow (my unpublished data). Claman, Chaperon and Triplett3 have shown that the transfer of thymus cells alone to irradiated recipient mice would not restore their antibody response to sheep erythrocyte antigens, but that these cells would act in cooperation with bone marrow cells when a mixture of these cell types was transferred.
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Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. and Med., 122, 1167 (1966).
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TAYLOR, R. Immune Paralysis of Thymus Cells by Bovine Serum Albumin. Nature 220, 611 (1968). https://doi.org/10.1038/220611a0
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DOI: https://doi.org/10.1038/220611a0
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