Letter | Published:

Behavioural Effects of some Morphine Antagonists and Hallucinogens in the Rat

Nature volume 220, pages 586587 (09 November 1968) | Download Citation

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Abstract

Corne and Pickering1 found a good correlation between activity in inducing a behavioural response (head twitches) in mice and the hallucinogenic activity in man of several drugs, which included atropine, hyoscine, lysergide (LSD), mescaline, N,N-dimethyltryptamine, phencyclidine, psilocin and psilocybin. Drugs that did not cause head twitches in mice included the morphine antagonists cyclazocine (personal communication from S. J. Corne) and nalorphine, both of which are known to cause hallucinations in man2,3.

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Affiliations

  1. Department of Pharmacological Research, Parke, Davis and Company, Hounslow, Middlesex.

    • C. SCHNEIDER

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DOI

https://doi.org/10.1038/220586a0

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