Abstract
Corne and Pickering1 found a good correlation between activity in inducing a behavioural response (head twitches) in mice and the hallucinogenic activity in man of several drugs, which included atropine, hyoscine, lysergide (LSD), mescaline, N,N-dimethyltryptamine, phencyclidine, psilocin and psilocybin. Drugs that did not cause head twitches in mice included the morphine antagonists cyclazocine (personal communication from S. J. Corne) and nalorphine, both of which are known to cause hallucinations in man2,3.
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References
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SCHNEIDER, C. Behavioural Effects of some Morphine Antagonists and Hallucinogens in the Rat. Nature 220, 586–587 (1968). https://doi.org/10.1038/220586a0
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DOI: https://doi.org/10.1038/220586a0
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