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Nicotine, Smoking and Cortical Inhibition


THE identification of a system of inhibitory cholinergic synaptic receptors on neurones in the cerebral cortex has been described1–3. Further investigation of the pharmacological properties of these receptors revealed that iontophoretically applied nicotine was as effective as acetylcholine (ACh) in depressing cortical neurones and led to a consideration of the relationship between cortical inhibition, nicotine and smoking.

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PHILLIS, J., YORK, D. Nicotine, Smoking and Cortical Inhibition. Nature 219, 89–91 (1968).

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