Abstract
THE identification of a system of inhibitory cholinergic synaptic receptors on neurones in the cerebral cortex has been described1–3. Further investigation of the pharmacological properties of these receptors revealed that iontophoretically applied nicotine was as effective as acetylcholine (ACh) in depressing cortical neurones and led to a consideration of the relationship between cortical inhibition, nicotine and smoking.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Phillis, J. W., and York, D. H., Brain Res., 5, 517 (1967).
Phillis, J. W., and York, D. H., Nature, 216, 922 (1967).
Phillis, J. W., and York, D. H., Life Sci., 7, 65 (1968).
Larson, P. S., Haag, H. B., and Silvette, H., Tobacco: Experimental and Clinical Studies; A Comprehensive Account of the World Literature (Williams and Wilkins Company, Baltimore, 1961).
Johnston, L. M., Lancet, 243, 742 (1942).
Dixon, W. E., Lancet, 201 (II), 1071 (1921).
Knapp, D. E., and Domino, E. F., Intern. J. Neuropharmacol., 1, 333 (1962).
Lambiase, M., and Serra, C., Acta Neurol. Naples, 12, 475 (1957).
Phillis, J. W., and York, D. H., Brain Res. (in the press).
Armitage, A. K., Milton, A. S., and Morrison, C. F., Brit. J. Pharmacol. Chemother., 27, 33 (1966).
Armitage, A. K., and Hall, G. H., Nature, 214, 977 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PHILLIS, J., YORK, D. Nicotine, Smoking and Cortical Inhibition. Nature 219, 89–91 (1968). https://doi.org/10.1038/219089a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/219089a0
This article is cited by
-
Supersensitivity and Dependence
Nature (1968)
-
Nicotine, Smoking and Cortical Activation
Nature (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.