Abstract
IMMUNE tolerance has been established to a variety of antigens in many animal species1, but few data are available for humans2. The ease of inducing immune tolerance varies inversely with the maturity of the subject and the potency of the antigen. Humans are immunologically immature at birth. The ability to synthesize immunoglobulin G is limited until 3 months of age, and does not approach normal levels until 6 months of age or older3, so an attempt was made to induce immune tolerance in humans at birth.
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PIROFSKY, B., CORDOVA, M., ACNAYO, A. et al. Production of Immune Tolerance in Humans. Nature 218, 284–286 (1968). https://doi.org/10.1038/218284a0
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DOI: https://doi.org/10.1038/218284a0
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