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Human Chromosomology: Segregation of Chromatids in Diploid Cells in vitro

Abstract

STUDIES of the segregation of chromatids during mitotic anaphase may contribute to a better understanding of certain aspects of cell division. Thus autoradiographic methods used with mouse embryonic cell cultures and root tips of Vicia faba and Triticum boeoticum1–3 have shown that the segregation of chromatids in those cells is a non-random process. Earlier work had shown that the segregation of DNA strands in Escherichia coli is non-random4,5. Recently published evidence, however, shows that in Bacillus subtilis the segregation of DNA strands is random6. I have obtained results which indicate that in human cells the segregation of chromatids during mitotic anaphase is random.

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CUEVAS-SOSA, A. Human Chromosomology: Segregation of Chromatids in Diploid Cells in vitro. Nature 218, 1059–1061 (1968). https://doi.org/10.1038/2181059a0

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