Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets

Abstract

The action of thrombin on fibrinogen is not responsible for its effect on platelets. Thrombin does, however, have an enzyme effect on a platelet constituent: this requires an unsubstituted serine hydroxyl group and a group susceptible to acetylation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Laki, K., and Gladner, J. A., Physiol. Rev., 44, 127 (1964).

    CAS  Article  Google Scholar 

  2. 2

    Davey, M. G., and Lüscher, E. F., in Proc. Third Meeting Fed. Europ. Biochem. Soc., Warsaw, 1966, Biochemistry of Blood Platelets, 9 (Academic Press, London and New York, 1967).

    Google Scholar 

  3. 3

    Morse, E. E., Jackson, D. P., and Conley, C. L., J. Clin. Invest., 44, 809 (1965).

    CAS  Article  Google Scholar 

  4. 4

    Mihalyi, E., and Godfrey, J. E., Biochim. Biophys. Acta, 67, 73 (1963).

    CAS  Article  Google Scholar 

  5. 5

    Blombäck, B., and Yamashima, I., Ark. Kemi, 12, 299 (1958).

    Google Scholar 

  6. 6

    Didisheim, P., and Lewis, J. H., Proc. Soc. Exp. Biol. and Med., 93, 10 (1956).

    CAS  Article  Google Scholar 

  7. 7

    Nahas, L., Denson, K. W. E., and Macfarlane, R. G., Thrombos. Diathes. Haemorrh., 12, 355 (1964).

    CAS  Article  Google Scholar 

  8. 8

    Davey, M. G., and Lüscher, E. F., Nature, 207, 730 (1965).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Davey, M. G., and Lüscher, E. F., in Proc. Tenth Cong. Europ. Soc. Haemat., Strasbourg, 1965, 1118 (S. Karger, Basel, 1967).

    Google Scholar 

  10. 10

    Bettex-Galland, M., and Lüscher, E. F., Thrombos. Diathes. Haemorrh., 4, 178 (1960).

    CAS  Article  Google Scholar 

  11. 11

    Rosen, H., Arch. Biochem., 67, 10 (1957).

    CAS  Article  Google Scholar 

  12. 12

    Soulier, J. P., and Prou-Wartelle, O., Thrombos. Diathes. Haemorrh., 17, 321 (1967).

    CAS  Article  Google Scholar 

  13. 13

    Sherry, S., and Troll, W., J. Biol. Chem., 208, 95 (1954).

    CAS  PubMed  Google Scholar 

  14. 14

    Markwardt, F., Barthel, W., Glusa, E., and Hoffmann, A., Naunyn-Schmiedbergs Arch. Exp. Pathol. Pharmacol., 252, 297 (1966).

    CAS  Article  Google Scholar 

  15. 15

    Marcus, A. J., and Zucker, M. B., The Physiology of Blood Platelets, 63 (Grune and Stratton, New York, 1965).

    Google Scholar 

  16. 16

    Engel, A., and Alexander, B., Biochemistry, 5, 3590 (1966).

    CAS  Article  Google Scholar 

  17. 17

    Engel, A., Alexander, B., and Pechet, L., Biochemistry, 5, 1543 (1966).

    CAS  Article  Google Scholar 

  18. 18

    Lüscher, E. F., Ergebn. Physiol., 50, 1 (1959).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

DAVEY, M., LÜSCHER, E. Actions of Thrombin and Other Coagulant and Proteolytic Enzymes on Blood Platelets. Nature 216, 857–858 (1967). https://doi.org/10.1038/216857a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.