Abstract
THE measurement of the diffusion coefficient of oxygen through actively respiring tissue is of considerable interest but presents some practical difficulty. From the work of Krogh in 1918 until the present time, a very wide range of values for oxygen diffusion coefficients has been reported1–5 ranging from 1.1 × 10−4 to 4 × 10−8 cm2 sec−1. Because of this very wide range of reported values we decided to measure this value again by a technique essentially similar to that described by Longmuir5, but with the difference that the measurements were made on one slice of tissue at a time without the intrusion of “edge” effects.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Krogh, A., J. Physiol., 52, 391 (1918/19).
Hill, A. V., Proc. Roy. Soc. B., 104, 39 (1928).
Kirk, J. E., and Johnson, S. G., Circulation, 4, 478 (1951).
Rashevsky, N., Mathematical Biophysics, 1, 42 (Dover Publications. New York, 1960).
Longmuir, I. S., Biochem. J., 76, 225 (1960).
MacDougall, J. D. B., and Coupland, R. E., Exp. Cell. Res., 45, 385 (1967).
Warburg, O., Biochem. Z., 142, 317 (1923).
Longmuir, I. S., and Clarke, B. J., Biochem. J., 63, 57 (1956).
McCabe, M., and Gilbert, D., Nature, 208, 450 (1965).
Jordan, J., Ackerman, E., and Berger, R. L., J. Amer. Chem. Soc., 78, 2979 (1956).
Trowell, O. A., Exp. Cell. Res., 16, 118 (1959).
Shoup, C. S., J. Gen. Physiol., 13, 27 (1929).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MACDOUGALL, J., MCCABE, M. Diffusion Coefficient of Oxygen through Tissues. Nature 215, 1173–1174 (1967). https://doi.org/10.1038/2151173a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2151173a0
This article is cited by
-
A Mechanistic Analysis of Possible Blood Transfusion Failure to Increase Circulatory Oxygen Delivery in Anemic Patients
Annals of Biomedical Engineering (2019)
-
Histological investigation of the titanium fiber mesh with one side sealed with non-porous material for its application to the artificial heart system
Journal of Artificial Organs (2018)
-
Simulation-assisted design of microfluidic sample traps for optimal trapping and culture of non-adherent single cells, tissues, and spheroids
Scientific Reports (2017)
-
Estimation of dynamic metabolic activity in micro-tissue cultures from sensor recordings with an FEM model
Medical & Biological Engineering & Computing (2016)
-
Epigenetic regulation of CD34 and HIF1A expression during the differentiation of human mast cells
Immunogenetics (2013)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
