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Phytohaemagglutinin Unresponsiveness of Lymphocytes from Babies with Congenital Rubella

Abstract

SINCE the rubella epidemic in the United States in the spring of 1964, numerous cases of congenital rubella have been reported. In addition to the characteristics described by Gregg1 of congenital heart defects, central nervous system damage, deafness and eye defects, there have been manifestations of progressing infection including failure to thrive, hepatosplenomegaly, thrombocytopenic purpura and bony lesions2. Rubella virus has been isolated from the urine, throat washings and blood of babies with congenital rubella2,3, and in addition from many organs including lymphoid tissues at post-mortem examinations3,4.

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OLSON, G., SOUTH, M. & GOOD, R. Phytohaemagglutinin Unresponsiveness of Lymphocytes from Babies with Congenital Rubella. Nature 214, 695–696 (1967). https://doi.org/10.1038/214695a0

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