Letter | Published:

Selective Deamination of Nucleosides by 2,4-Dinitrophenyl Hydrazine

Naturevolume 214page402 (1967) | Download Citation

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Abstract

NUCLEOPHILIC substitution by semicarbazide in cytidine and its derivatives has been reported1. Such alterations of nucleic acid bases is an essential preliminary to the formation of synthetic “genetic messengers” to serve in the chemotherapy of growth abnormalities. Generally, methods for the synthesis of derivatives of nucleosides are of wide applicability to genetic problems. There is particular chemical interest in the reactions of dinitrophenyl hydrazine with nucleosides because the reagent replaces, in a specific manner, amino groups without respect to their position in a pyrimidine or purine ring.

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References

  1. 1

    Hayatsu, H., Takeishi, K., and Ukita, T., Biochim. Biophys. Acta, 123, 445 (1966).

  2. 2

    Gilham, P. T., J. Amer. Chem. Soc., 84, 687 (1962).

  3. 3

    Michelson, A. M., The Chemistry of Nucleosides and Nucleotides, 20 (Academic Press, London, 1963).

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Author information

Affiliations

  1. Department of Biochemistry, University of Texas Medical Branch, Galveston, Texas

    • ANIL B. PATEL
    •  & HARRY DARROW BROWN

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https://doi.org/10.1038/214402a0

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