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Suppression of Plasma Immunoreactive Insulin in Rats given D-Mannoheptulose

Naturevolume 214pages276277 (1967) | Download Citation



SIMON and co-workers1–3 produced marked hyperglycaemia in the fasting rat with a single injection of D-mannoheptulose, a seven carbon sugar found in avocados. Their work suggests that heptulose blocks normal pancreatic secretion of insulin in response to glucose and that it induces gluconeogenesis. Coore et al.4 have demonstrated in rabbit pancreas slices that mannoheptulose blocks the glucose-stimulated release of insulin. The present investigation provides evidence that in the intact rat mannoheptulose suppresses the increase in plasma immunoreactive insulin (IRI) normally elicited by hyperglycaemia.

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  1. 1

    Simon, E., and Kraicer, P. F., Arch. Biochem. Biophys., 69, 592 (1957).

  2. 2

    Simon, E., Kraicer, P. F., and Shelesnyak, M. C., Endocrinology, 71, 83 (1962).

  3. 3

    Simon, E., Kraicer, P. F., and Shelesnyak, M. C., Endocrinology, 71, 90 (1962).

  4. 4

    Coore, H. G., Randle, P. J., Simon, E., Kraicer, P. F., and Shelesnyak, M. C., Nature, 197, 1264 (1963).

  5. 5

    Yalow, R. S., and Berson, S. A., J. Clin. Invest., 39, 1151 (1960).

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    Dische, Z., J. Biol. Chem., 204, 983 (1953).

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    De Bodo, R. C., and Altszuler, N., Physiol. Rev., 38, 389 (1958).

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  1. Department of Pediatrics, Albert Einstein College of Medicine, New York, New York

    •  & PAUL WINICK


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