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Cause of Homologous Disease

Abstract

When hybrid mice are injected with spleen cells from one of the parent strains, they develop symptoms leading to death. Animals dying from this “homologous disease” frequently have enlarged adrenal glands. The possibility that this disease results from adrenal hyperactivity is explored by investigating two of its features—thymic involution and reactions of peripheral lymphoid tissue.

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HEIM, L., MARTINEZ, C. & GOOD, R. Cause of Homologous Disease. Nature 214, 26–29 (1967). https://doi.org/10.1038/214026a0

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