Abstract
THE serum of many conventional and so-called germ-free animals contains bactericidal activity against certain Gram-negative bacteria1. This activity is effective against those bacteria commonly found in the intestinal tract or bacteria related to them. Even the feeding of heat-killed bacteria to germ-free chicks results in specific agglutinin2. Thus it appears that antigens from the lumen of the gut may become transported to sites of antibody synthesis. It is well established that gamma globulin and possibly other serum globulins are decreased in germ-free animals3–5. All immunoglobulins were markedly decreased in the germ-free mouse6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Landy, M., and Weidanz, W. P., in Bacterial Endotoxins, 275 (edit. by Landy M., and Braun, W.) (Institute of Microbiology, Rutgers, New Brunswick, New Jersey, 1964).
Wagner, M., Ann. N.Y. Acad. Sci., 78, 261 (1959).
Thorbecke, G. J., Gordon, H. A., Wostmann, B., Wagner, M., Reyniers, J. A., J. Infect. Dis., 101, 237 (1957).
Gustafson, B., and Laurell, C.-B., J. Exp. Med., 108, 251 (1958).
Wostmann, B. S., Olson, G. B., and Pleasants, J. R., Nature, 206, 1056 (1965).
Fahey, J. L., and Sell, S., J. Exp. Med, 122, 41 (1965).
Winner, J. H., and Hurley, R., Candida albicans (J. and A. Churchill Ltd., 1964).
Phillips, A. W., Newcomb, H. R., Lachapelle, R. C., and Balish, E., App. Microbiol., 10, 224 (1962).
Trexler, P. C., Lab. Animal Care, 13, 572 (1963).
Wagner, M., Ann. N.Y. Acad. Sci., 78, 89 (1959).
Miler, I., Kostka, J., Simek, L., and Lanc, A., Folia Microbiol. (Prague), 9, 277 (1964).
Reyniers, J. A., Ann. N.Y. Acad. Sci., 78, 1 (1959).
Phillips, A. W., and Smith, J. E., Adv. App. Microbiol., 1, 141 (1959).
Mickelsen, O., Ann. Rev. Biochem., 31, 515 (1962).
Luckey, T. D., Germ-free Life and Gnotobiology (Academic Press, New York, 1963).
Pollard, M., Science, 145, 247 (1964).
Levinson, S. M., and Tennant, B., Fed. Proc., 22, 109 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PHILLIPS, A., LACHAPELLE, R. Serum Proteins in the Germ-free Mouse after Oral Challenge with Candida albicans. Nature 213, 709–710 (1967). https://doi.org/10.1038/213709a0
Issue Date:
DOI: https://doi.org/10.1038/213709a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.