Abstract
RECENT evidence indicates that thymectomy in newborn laboratory animals of some species may result in immunological deficiencies. These may become manifest as compromised capacity to form circulating antibodies1, as delayed homograft rejection2,3, as diminished capacity to develop tuberculin-type sensitivities1, and as lowered resistance to infection1. These deficiencies may be related to a reduction in the number of circulating lymphocytes and a failure of germinal centre development, as observed in neonatally thymectomized mice2.
Similar content being viewed by others
Article PDF
References
Janhovic, B. D., Waksman, B. H., and Arnason, B. G., J. Exp. Med., 116, 159 (1962).
Miller, J. F. A. P., Lancet, ii, 748 (1961).
Dalmasso, A. P., Martinex, C., and Good, R. A., Proc. Soc. Exp. Biol. And Med., 11, 143 (1962).
Baer, R. L., and Yanowitz, M., J. Allerg., 232, 95 (1952).
Landsteiner, K., and Chase, H. W., Proc. Soc. Exp. Biol. and Med., 49, 688 (1942).
Baer, R. L., and Sulzberger, M. B., J. Invest. Dermat., 18, 53 (1952).
Epstein, W., and Kligman, A. M., J. Invest. Dermat., 28, 291 (1957).
Frey, J. R., and Wenk, P., Int. Arch. Allerg., 11, 81 (1957).
Good, R. A., Finstad, J., and Gabrielsen, A. E., World Wide Abst. Gen. Med., 7, 12 (1964).
Rosen, F. S., Gitlin, D., and Janeway, C. A., Lancet, ii, 380 (1962).
Park, E. A., J. Exp. Med., 25, 129 (1917).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BART, R., STRITZLER, R. & BAER, R. Failure of Thymectomy in New-born Guinea-pigs to influence Contact Sensitization. Nature 210, 1176 (1966). https://doi.org/10.1038/2101176a0
Issue Date:
DOI: https://doi.org/10.1038/2101176a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.