Abstract
IT has been shown that bone marrow allografts in supralethally X-irradiated dogs transform into lymphoid cells1. Soon after transplantation, so-called ‘hyperbasophilic’ cells may be observed in bone marrow punctures, and within 6–7 days they and transitional to small lymphocyte forms appear in great numbers in the peripheral blood. We have supposed that these lymphoid cells transformed from bone marrow stem cells are immuno-logically competent cells which are able to induce the ‘graft-versus-host’ reaction. This communication presents some evidence for this hypothesis. The participation of these cells in transplantation immunity was tested by their ability to induce a hypersensitivity reaction of the delayed type, called a ‘transfer reaction’ by Brent et al.2.
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Mannick, J. A., and Egdahl, R. H., Science, 137, 976 (1962); Ann. Surg., 156, 356 (1962).
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SAMOYLINA, N., CHERTKOV, I. Graft-versus-host Specificity of Lymphoid Cells transformed from Bone Marrow Allograft in Supralethally X-irradiated Dogs. Nature 210, 108 (1966). https://doi.org/10.1038/210108a0
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DOI: https://doi.org/10.1038/210108a0
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