Abstract
IT has been widely demonstrated that in vivo application of carcinostatic agents inhibits the host immune response, namely, inhibition of antibody production by antimetabolites1–4, alkylating agents1,5 and antibiotics6,7, and prolongation of homograft survival by a nitrogen mustard derivative8. Investigations of the mode of action of these agents on the immune function of lymphoid cells sensitized with homologous cells would provide interesting information on the mechanism of action of the lymphoid cells in transplantation immunity, since some of these agents have been known to act on the specific sites of the cellular functions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Berenbaum, M. C., Nature, 196, 384 (1962).
Rosenberg, S., and Calabresi, P., Nature, 199, 1101 (1963).
Schwartz, R., and Damesheck, W., J. Clin. Invest., 39, 952 (1960).
Sahiar, K., and Schwartz, R. S., Science, 145, 395 (1964).
Brown, I. N., and Barenbaum, M. C., Nature, 201, 1340 (1964).
Butlar, W. T., Fed. Proc., 20, 27 (1961).
Brown, I. N., Nature, 204, 487 (1964).
Berenbaum, M. C., and Brown, I. N., Nature, 200, 84 (1963).
Ishidate, M., Hashimoto, Y., Odashima, S., and Sudo, H., Gann, 56, 13 (1965).
Hashimoto, Y., Ishidate, M., and Takaku, M., Gann, 56, 23 (1965).
Bloom, B. R., Hamilton, L. D., and Chase, M. W., Nature, 201, 689 (1964).
Uhr, J. W., Science, 142, 1476 (1963).
Weiler, E., Science, 144, 846 (1964).
Svehag, S., Science, 146, 659 (1964).
Reich, E., Franklin, R. M., Shatkin, A. J., and Tatum, E. L., Proc. U.S. Nat. Acad. Sci., 48, 1238 (1962).
Shatkin, A., Reich, E., Franklin, R. M., and Tatum, E. L., Biochim. Biophys. Acta, 55, 277 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HASHIMOTO, Y., SUDO, H. & ISHIDATE, M. Inhibitory Effect of Carcinostatic Agents on Antitumour Activity of Immune Lymphoid Cells. Nature 209, 1360–1361 (1966). https://doi.org/10.1038/2091360a0
Issue Date:
DOI: https://doi.org/10.1038/2091360a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
