Abstract
CLOREXOLONE (M and B 8430) is a powerful oral diuretic1 with pronounced antihypertensive properties even when administered in sub-diuretic doses2. It has certain structural features in common with chlorothiazide and with chlorthalidone, but is unique in containing the cyclohexane-isoindoline structure.
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CORBETT, K., EDWARDS, S., LEE, G. et al. Metabolism of 5-Chloro-2-cyclohexyl-l-oxo-6-sulphamoyl Isoindoline, Clorexolone (M and B 8430). Nature 208, 286–287 (1965). https://doi.org/10.1038/208286a0
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DOI: https://doi.org/10.1038/208286a0
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