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Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021

The Journal of Antibiotics volume 73, pages 365–371 (2020)Cite this article

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Abstract

Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 µM.

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Acknowledgements

We thank Dr K. Nagai and Ms N. Sato (School of Pharmacy, Kitasato University) for various instrumental analyses. We thank Dr T. Nakashima (Kitasato Institute for Life Sciences, Kitasato University) for ESI-MS/MS analysis. We thank Dr A. Také (School of Medicine, Kitasato University) for useful suggestion concerning the experiments. This study was supported by Okinawan Create Leading Projects in Growing Fields 2017–2019, OKINAWA Prefectural Government. This study was also partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from the Japan Agency for Medical Research & Development (AMED) under grant number JP19am0101096. This research was also partially supported by AMED under grant number 18ae0101047.

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  1. These authors contributed equally: Takahito Ouchi, Yoshihiro Watanabe

Authors and Affiliations

  1. Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Takahito Ouchi, Kenichi Nonaka, Aki Ishiyama, Yukihiro Asami, Yuki Inahashi & Masato Iwatsuki

  2. Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan

    Yoshihiro Watanabe, Kenichi Nonaka, Reiko Muramatsu, Chikako Noguchi, Miho Tozawa, Rei Hokari, Aki Ishiyama, Hidehito Matsui, Yukihiro Asami, Yuki Inahashi, Masato Iwatsuki, Hideaki Hanaki & Satoshi Ōmura

  3. Graduate School of Science, Kitasato University, 1-15-1, Kitazato, Minami, Sagamihara, Kanagawa, 252-0373, Japan

    Rima Koike

  4. Faculty of Agriculture, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa, 903-0213, Japan

    Takahiro Ishii

  5. Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa, 903-0213, Japan

    Toshiaki Teruya

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Correspondence to Masato Iwatsuki.

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Ouchi, T., Watanabe, Y., Nonaka, K. et al. Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021. J Antibiot 73, 365–371 (2020). https://doi.org/10.1038/s41429-020-0292-7

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