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Ultrastructure of Antibody-forming Cells

Nature volume 207, pages 994–995 (1965)Cite this article

Abstract

THE method of Jerne and Nordin for demonstrating individual antibody-forming lymphoid cells has been utilized to obtain quantitative information about the cellular changes during antibody formation1, to indicate transplantation immunity2 and to demonstrate antibody-forming cells in ‘tolerant’ animals3. Recently, this method has been combined with autoradiography to investigate the kinetics of antibody formation4. In the present studies the plaque method has been used to identify for study by electron microscopy individual cells which have released antibody.

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References

  1. Jerne, N. K., and Nordin, A. A., Science, 140, 405 (1963). Jerne, N. K., Nordin, A. A., and Henry, C., in Cell-bound Antibodies, edit. by Amor, B., and Koprowski, H., 109 (Wistar Inst. Press, Philadelphia, 1963).

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Author notes

  1. F. W. FITCH: John and Mary R. Markle scholar in academic medicine.

  2. D. A. ROWLEY: U.S. Public Health Service Senior Research Fellow.

  3. S. COULTHARD: Predoctoral trainee, supported by U.S. Public Health Service medical training grant 2-TI-AI 96–05 from the Department of Health, Education and Welfare, National Institutes of Health.

Authors and Affiliations

  1. Department of Pathology, University of Chicago,

    F. W. FITCH, D. A. ROWLEY & S. COULTHARD

Authors
  1. F. W. FITCH
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  2. D. A. ROWLEY
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  3. S. COULTHARD
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FITCH, F., ROWLEY, D. & COULTHARD, S. Ultrastructure of Antibody-forming Cells. Nature 207, 994–995 (1965). https://doi.org/10.1038/207994a0

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