Letter | Published:

Non-essential Role of the Adrenal Medulla in the Hibernation of the 13-Lined Ground Squirrel

Naturevolume 207pages656657 (1965) | Download Citation



ALTHOUGH the adrenal cortical hormones are reported to be necessary for successful hibernation and arousal in European ground squirrels, Citellus citellus1, and in European hamsters, Cricetus cricetus2, the necessity and function of the adrenal medullary hormones are still in doubt. Most investigators agree, however, that these catecholamines, especially norepinephrine, are probably involved in chemical heat production by torpid and arousing hibernators3–5. Although totally adrenalectomized hibernating animals arouse in a nearly normal manner, a return to normal hibernating patterns is prevented unless adrenal cortical tissue is transplanted into the anterior chamber of the eye or unless cortisone or deoxycorticosterone acetate (DCA) is administered1,2. Presumably, then, the hormones of the adrenal medulla are not needed for at least short ‘bouts’ of hibernation or for arousal, even though the importance of the sympathetico-adrenal system in spontaneous arousal has been repeatedly emphasized4,6–8.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Vidovic, V. L., and Popovic, V., J. Endocrinol., 11, 125 (1954).

  2. 2

    Kayser, C., and Petrovic, A., C.R. Soc. Biol., 152, 519 (1958).

  3. 3

    Suomalainen, P., and Uuspää, V. J., Nature, 182, 1500 (1958).

  4. 4

    Kayser, C., The Physiology of Natural Hibernation, 325 (Pergamon Press, Ltd., London, 1961).

  5. 5

    Uuspää, V. J., Ann. Med. Exp. Fenn., 41, 349 (1963).

  6. 6

    Kayser, C., Ann. Physiol., 16, 314 (1940).

  7. 7

    Chatfield, P. O., and Layman, C. P., Amer. J. Physiol., 163, 566 (1950).

  8. 8

    Hiebel, G., and Kayser, C., J. Physiol., (Paris), 42, 606 (1950).

  9. 9

    Kayser, C., Arch. Sci. Physiol., 6, 193 (1952).

  10. 10

    Pengelley, E. T., and Fisher, K. C., Canad. J. Zool., 39, 105 (1961).

  11. 11

    Adler, L., Handb. Norm. Path. Physiol., 17, 105 (1926).

  12. 12

    Kayser, C., and Aron, M., Arch. Anat. Histol. Embrol., 33, 21 (1950).

  13. 13

    Petrovic, V. M., and Davidovic, V., C.R. Soc. Biol., 157, 1175 (1963).

Download references

Author information

Author notes

    • R. A. HOFFMAN

    Present address: Department of Biology, Colgate University, Hamilton, New York


  1. U.S. Army Edgewood Arsenal, Chemical Research and Development Laboratories, Edgewood Arsenal, Maryland

    • R. A. HOFFMAN
    •  & R. J. HESTER


  1. Search for R. A. HOFFMAN in:

  2. Search for R. J. HESTER in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.