Transauricular Perfusion of the Pituitary Gland in Rats and Mice

Abstract

So far as we know, intrapituitary injections1–7 or implants8–15 have been performed only on adult rats1–5,8–11 or on bigger animals such as rabbits6,7,12–14 or dogs15. For these experiments stereotaxic methods are usually adopted. In this communication a technique is described which renders it possible to perform injections or perfusions into the pituitary gland of both immature and adult rats and mice. To this purpose a needle has been devised which allows entrance to the hypophyseal tissue by the transauricular approach. Such a route had been already used to perform, with suitable instruments, both pituitary ablation16,17 and transplantation18.

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ROSSI, G., FALCONI, G. Transauricular Perfusion of the Pituitary Gland in Rats and Mice. Nature 207, 1200–1202 (1965). https://doi.org/10.1038/2071200b0

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