Isolation and Identification of 2-Aminoethyl-phosphonic Acid from Bovine Brain

Abstract

IN the course of isolating unidentified amino-compounds from bovine brain1–3, a substance was isolated from the neutral amino-acid fraction of the trichloroacetic acid of the brain, and was identified as 2-aminoethylphosphonic acid from the results of elementary analysis, infra-red spectrography and chromatography. The occurrence of 2-aminoethylphosphonic acid in protozoa4,5 and in the sea anemone6 has been reported both in free and combined form; but its presence in the higher animals has not been reported in either form until now.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Kakimoto, Y., Nakajima, T., Kanazawa, A., Takesada, M., and Sano, I., Biochim. Biophys. Acta, 93, 333 (1964).

  2. 2

    Kanazawa, A., Kakimoto, Y., Nakajima, T., Shimizu, H., Takesada, M., and Sano, I., Biochim. Biophys. Acta. (in the press).

  3. 3

    Kakimoto, Y., and Kanazawa, A. (unpublished results).

  4. 4

    Horiguchi, M., and Kandatsu, M., Nature, 184, 901 (1959).

  5. 5

    Kandatsu, M., and Horiguchi, M., Arg. Biol. Chem., 26, 721 (1962).

  6. 6

    Kittredge, J. S., Roberts, E., and Simonsen, D. G., Biochemistry, 1, 624 (1962).

  7. 7

    Kakimoto, Y., and Armstrong, M. D., J. Biol. Chem., 236, 3280 (1961).

  8. 8

    Kandatsu, M., and Horiguchi, M., Agric. Biol. Chem., 28, 408 (1964).

  9. 9

    Rosenberg, H., Nature, 203, 299 (1964).

  10. 10

    Horiguchi, M., and Kandatsu, M. (personal communication).

  11. 11

    Rouser, G., Kritchevsky, G., Heller, D., and Lieber, E., J. Amer. Oil. Chem. Soc., 40, 425 (1963).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

SHIMIZU, H., KAKIMOTO, Y., NAKAJIMA, T. et al. Isolation and Identification of 2-Aminoethyl-phosphonic Acid from Bovine Brain. Nature 207, 1197–1198 (1965). https://doi.org/10.1038/2071197a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.