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Auditory collusion and a coupled couple of outer hair cells

Nature volume 399, pages 359–362 (1999)Cite this article

Abstract

The discrepancies between measured frequency responses of the basilar membrane in the inner ear and the frequency tuning found in psychophysical experiments led to Békésy's idea of lateral inhibition in the auditory nervous system1. We now know that basilar membrane tuning can account for neural tuning2, and that sharpening of the passive travelling wave depends on the mechanical activity of outer hair cells (OHCs)3, but the mechanism by which OHCs enhance tuning remains unclear. OHCs generate voltage-dependent length changes at acoustic rates4,5,6,7,8, which deform the cochlear partition9,10,11. Here we use an electrical correlate of OHC mechanical activity, the motility-related gating current, to investigate mechano-electrical interactions among adjacent OHCs. We show that the motility caused by voltage stimulation of one cell in a group evokes gating currents in adjacent OHCs. The resulting polarization in adjacent cells is opposite to that within the stimulated cell, which may be indicative of lateral inhibition. Also such interactions promote distortion and suppression in the electrical and, consequently, the mechanical activity of OHCs. Lateral interactions may provide a basis for enhanced frequency selectivity in the basilar membrane of mammals.

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Figure 1: Adjacent OHCs are mechano-electrically coupled.
Figure 2: Both OHCs were voltage clamped to −80 mV, and OHC 1 was stepped to 70 mV (V c1).
Figure 3: Gating currents are a function of both OHCs' holding potential.
Figure 4: Both OHCs were voltage clamped to −40 mV and independently stimulated with pure sine-wave voltages.

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Acknowledgements

We thank M. Mazzucco for technical help. This work was supported by a grant from NINCDS to J.S.S.

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  1. Sections of Otolaryngology and Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven , 06510, Connecticut, USA

    Hong-Bo Zhao & J. Santos-Sacchi

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  1. Hong-Bo Zhao
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Correspondence to J. Santos-Sacchi.

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Zhao, HB., Santos-Sacchi, J. Auditory collusion and a coupled couple of outer hair cells. Nature 399, 359–362 (1999). https://doi.org/10.1038/20686

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