Abstract
THE inhibition of an oncogenic virus by a halogenated deoxyribonucleoside was first demonstrated by co-operating groups at the U.S. National Institutes of Health and Yale University1. They showed that the development of adenovirus 12-induced subcutaneous tumours in neonatal hamsters could be suppressed by either a single injection of 5-iodo-2′-deoxyuridine (IUdR) given at the same subcutaneous site as the virus, or even at a site distant from the virus injection using 10 subcutaneous doses of IUdR given on alternate days. This dosage of drug was apparently quite non-toxic.
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FISCHER, D., BLACK, F. & WELCH, A. Inhibition by Nucleoside Analogues of Tumour Formation by Polyoma Virus. Nature 206, 839–840 (1965). https://doi.org/10.1038/206839b0
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DOI: https://doi.org/10.1038/206839b0
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