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Narcotic Analgesics: Possibility of Broadening the Structural Basis of Analgesics

Nature volume 206, pages 1151–1152 (1965)Cite this article

Abstract

MORPHINE, and its chemical congeners with similar pharmacological activity, tend to fall into a common structural pattern. They are generally tertiary nitrogen bases, −NR3, characterized by the usual sp3 tetrahedral bonding. The actual base function is performed by the unshared pair of electrons on the nitrogen. They have a centrally located, quaternary carbon atom, and an aryl group or groups attached directly to the central carbon atom, and the central carbon is separated from the nitrogen by a two-carbon chain (sp3 bonded).

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Authors and Affiliations

  1. Bristol-Myers Products Division, Hillside, New Jersey

    ARMIN WILSON & ANTHONY W. PIRCIO

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  1. ARMIN WILSON
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  2. ANTHONY W. PIRCIO
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WILSON, A., PIRCIO, A. Narcotic Analgesics: Possibility of Broadening the Structural Basis of Analgesics. Nature 206, 1151–1152 (1965). https://doi.org/10.1038/2061151a0

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  • DOI: https://doi.org/10.1038/2061151a0

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