Abstract
I HAVE recently described the inhibitory effect of 6-aminonicotinamide (6-AN) on the growth of vaccinia virus in the chick embryo fibroblast (CEF) host cell system1. When CEF cultures were treated with 6-AN at a dose of 5 µg/ml. for an interval of 8 h at 36° C, it was found that 6-AN rendered the cells refractory to infection with vaccinia virus. This effect increased as the time of exposure to 6-AN lengthened up to 8 or 10 h before virus infection. Evidence was also obtained to show that the inhibitory effect produced by 5 µg/ml. of 6-AN could be reversed by the simultaneous addition of 5–50 µg ml. of nicotinamide, but not if it was added at a later time. The drug did not seem to exert a direct lethal effect on the virus.
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References
Lee, S. H. S., J. Bacteriol., 88, 885 (1964).
Armstrong, J. A., Exp. Cell Res., 11, 640 (1956).
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LEE, S. Further Observations on the Effect of 6-Aminonicotinamide on Chick Embryo Tissue Cultures infected with Vaccinia and other Viruses. Nature 205, 1242–1243 (1965). https://doi.org/10.1038/2051242b0
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DOI: https://doi.org/10.1038/2051242b0
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