Abstract
NORMAL human serum contains two kinds of macroglobulin, the γ1M (or β2M)-group and α2-macroglobulin; the latter was first isolated and described by Schultze and co-workers1. The macroglobulin isolated by Brown et al. from Cohn's Fraction III° seems to be the same protein2. Although α2-macroglobulin corresponds to about 3 per cent of total serum protein, its biological significance is still unknown. This may be a sufficient explanation for the rather scarce literature concerning it. However, it seems to us that the main reason might be the difficulty of obtaining this protein in a pure state and in sufficient quantity. This involves a complete fractionation scheme1,2, or the use of small-scale techniques involving ultracentrifugation or preparative electrophoresis3–5. A specific and simple isolation technique is still lacking.
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References
Schultze, H. E., Göllner, I., Heide, K., Schönenberger, M., and Schwick, G., Z. Naturf., 10b, 463 (1955).
Brown, R. K., Baker, W. H., Peterkofsky, A., and Kauffman, D., J. Amer. Chem. Soc., 76, 4244 (1954).
Müller-Eberhard, H. J., Kunkel, H. G., and Franklin, E. C., Proc. Soc. Exp. Biol. and Med., 93, 146 (1956).
Filitti-Wurmser, S., and Hartmann, L., Bull. Soc. Chim. Biol., 44, 919 (1962).
Picard, J. J., and Heremans, J. F., Biochim. Biophys. Acta, 71, 554 (1963).
Steinbuch, M., and Quentin, M., Nature, 190, 1121 (1961).
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STEINBUCH, M., QUENTIN, M. & PEJAUDIER, L. Specific Technique for the Isolation of Human α2-Macroglobulin. Nature 205, 1227–1228 (1965). https://doi.org/10.1038/2051227a0
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DOI: https://doi.org/10.1038/2051227a0
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