Letter | Published:

Action of Enzymatic Inhibitors (Potassium Cyanide and Sodium Fluoride) on Muscle Fibre Sensitivity to Potassium Ion

Nature volume 204, pages 586587 (07 November 1964) | Download Citation

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Abstract

THE experiments reported by Carey and Conway1 and by Conway2 on skeletal muscle, and by Hodgkin and Keynes3 on nerve fibre, show that ionic exchanges, especially sodium and potassium transfer, are related to aerobic metabolism in the living tissue. Therefore, metabolic inhibitors such as cyanides modify these exchanges between cell and surrounding medium by decreasing Na+ efflux and K+ influx.

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References

  1. 1.

    , and , Biochem. J., 64, 41P (1956).

  2. 2.

    , Physiol. Rev., 37, 84 (1957).

  3. 3.

    , and , J. Physiol., 128, 28 (1955).

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Author information

Affiliations

  1. Faculté de Pharmacie, Université de Paris.

    • GUILLAUME VALETTE
    •  & KEMAL OZAN

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DOI

https://doi.org/10.1038/204586a0

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