Abstract
Trans-1,4-bis (2-chlorobenzylaminomethyl) cyclohexane dihydrochloride (‘AY–9944’)1 has been shown to represent a novel class of cholesterol biosynthesis inhibitors which act by interfering with the enzymatic conversion of 7-dehydrocholesterol to cholesterol2,3. In laboratory animals, ‘AY–9944’ significantly depressed serum sterol-levels4. In view of its potential use as antihypercholesterolemic agent5, we have studied the effects of this agent on adrenal steroid metabolism. The inhibition of 11β-hydroxylase by ‘AY–9944’ in rat adrenal homogenates is reported herewith.
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GIVNER, M., KRAML, M., DVORNIK, D. et al. An Inhibitor of Adrenal Steroid 11β-Hydroxylase. Nature 203, 317 (1964). https://doi.org/10.1038/203317a0
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DOI: https://doi.org/10.1038/203317a0
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